Project leader : Kirsi Granberg, PhD

Faculty of Medicine and Life Sciences, University of Tampere

Brain tumor research project (led by Dr. Kirsi Granberg) represents a subgroup in Matti Nykter’s Computational Biology group. The project has a central role in Brain tumor research program, which is run in collaboration with Tampere University Hospital and Fimlab ltd.

We aim at understanding (1) how genetic and epigenetic alterations drive tumor development and progression, (2) how brain tumors respond to targeted interventions, and (3) how immune system is suppressed in brain tumors. Our main focus is on primary brain tumors, especially on gliomas. We also seek to develop tools for diagnostics and management e.g. through application of cell free tumor DNA analysis and immunohistochemistry.

In our program, we have access to an extensive retrospective sample collection, we have setup prospective brain tumor sample collection, and developed several patient-derived brain tumor cell cultures. We strongly utilize both experimental and computational approaches in our research and combine them with a goal to improve the handling and life of brain tumor patients.

Main collaborators: Hannu Haapasalo, MD, PhD, Joonas Haapasalo, MD, PhD, Kristiina Nordfors MD, PhD, Sven Nelander, MD, PhD, Prof. Wei Zhang